李慧颖

　　林源食品营养与人类健康（具有生物学、食品科学、基础医学、药学和生物信息学交叉研究背景）

2005年毕业于山东大学生命科学院（生物学学士）；
2011年毕业于清华大学生命科学学院（生物学博士）；
2015年生物信息学国家重点实验室（清华大学信息学院）博后出站。
2016年7月至2022年7月，中国农科院北京牧医所工作；
2022年7月至今，江南的注册网址生物学院工作。　　

　　截至2023年2月，发表SCI论文60余篇，其中以第一和通讯作者发表41篇（累计影响因子218分，他引557次）。主持或参与多项国家级、省部级项目和百万级横向项目，主持项目总经费410万元。以前三发明人申请国家发明专利12项，第一发明人5项。参与编写著作8部。在《Chinese Medicine》、《Frontiers in Physics》等期刊任编委和编辑。

近5年在天然成分领域以第一/通讯作者文章发表的SCI论文

• Lactoferrin suppresses the progression of colon cancer under hyperglycemia by targeting WTAP/m6A/NT5DC3/HKDC1 axis. Journal of Translational Medicine, 2023.
• Milk Active Ingredients, 2 ‘-fucosyllactose Inhibits Inflammation and Promotes MUC2 Secretion in LS174T Goblet Cells in vitro. Foods, 2022.
• Lactoferrin inhibits the development of T2D to colon tumors by regulating NT5DC3/PI3K/AKT/mTOR signaling pathway. Foods, 2022.
• Dynamic Regulation of eEF1A1 Acetylation Affects Colorectal Carcinogenesis. Biological Chemistry, 2022.
• Single-cell RNA-sequencing uncovers compound kushen injection synergistically improves the efficacy of chemotherapy by modulating the tumor environment of breast cancer. Frontiers in Immunology, 2022.
• Lactoferrin Alleviates Lipopolysaccharide-induced Infantile Intestinal Immune Barrier Damage By Regulating ELAVL1-related Signaling Pathway. International Journal of Molecular Sciences, 2022.
• 2’-Fucosyllactose Suppresses Angiogenesis and Alleviates Toxic Effects of 5-Fu in a HCT116 Colon Tumor-Bearing Model. Molecules, 2022.
• 2’-fucosyllactose Ameliorates Inflammatory Bowel Disease by Modulating Gut Microbiota and Promoting MUC2 Expression. Frontiers in Nutrition, 2022.
• Protective effects of recombinant lactoferrin with different iron saturations on enteritis injury in young mice. Journal of Dairy Science, 2022.
• Baicalin suppresses the progression of Type II diabetes-induced liver tumor through regulating METTL3/m6A/HKDC1 axis and downstream p-JAK2/STAT1/clevaged Caspase3 pathway. PHYTOmedicine, 2021.
• Alkaline phosphatase attenuates LPS-induced liver injury by regulating the miR-146a-related inflammatory pathway. International Immunopharmacology, 2021.
• The crosstalking between gut microbiome and immune response regulated by diet nutrients in inflammatory bowel disease. Foods, 2021.
• Lactoferrin could alleviate liver injury caused by Maillard reaction products with furan ring through regulating necroptosis pathway. Food Science & Nutrition, 2021.
• The combination of lactoferrin and linolenic acid inhibits colorectal tumor growth through activating AMPK/JNK-related apoptosis pathway. Peer J, 2021.
• Inhibitory effect of lactoferrin on pulmonary inflammatory process induced by lipopolysaccharide through modulating TLR4-related pathway. Journal of Dairy Science, 2021.
• Angustoline Inhibited Esophageal Tumors Through Regulating LKB1/AMPK/ELAVL1/LPACT2 Pathway And Phospholipid Remodeling. Frontiers in Oncology, 2020.
• Maillard reaction products with furan ring, like furosine, cause kidney injury through triggering ferroptosis pathway. Food Chemistry, 2020.
• Investigation and comparison of the protective activities of three functional proteins-lactoferrin, α-lactalbumin, and β-lactoglobulin in cerebral ischemia reperfusion injury. Journal of Dairy Science, 2020.
• The combination of two bioactive constituents, lactoferrin and linolenic acid, inhibits mouse xenograft esophageal tumor growth by downregulating lithocholyltaurine and inhibiting the JAK2/STAT3-related pathway. ACS Omega, 2020.
• Toxic effects of furosine by oral intake on liver and kidney and toxicokinetics research in mice acute toxicity model. Food Science and Technology Science, 2020.
• Modulation activity of heat-treated and untreated lactoferrin on the TLR-4 pathway in anoxia cell model and cerebral ischemia reperfusion mouse model. Journal of Dairy Science, 2019.
• Furosine, a Maillard Reaction Product, Triggers Necroptosis in Hepatocytes by Regulating the RIPK1/RIPK3/MLKL Pathway. International Journal of Molecular Sciences, 2019.
• Investigation and comparison of the anti-tumor activities of lactoferrin, α-lactalbumin and β-lactoglobulin, in A549/HT29/HepG2/MDA231-LM2 tumor models. Journal of Dairy Science, 2019.
• L-proline alleviates kidney injury caused by AFB1 and AFM1 through regulating excessive apoptosis of kidney cells. Toxins, 2019.
• Lactoferrin induces the synthesis of vitamin B6 and protects HUVEC functions by activating PDXP and the PI3K/AKT/ERK1/2 pathway. International Journal of Molecular Sciences, 2019.
• Furosine Posed Toxic Effects on Primary Sertoli Cells through Regulating Cep55/NF-kappa B/PI3K/Akt/FOX01/TNF-alpha Pathway. International Journal of Molecular Sciences, 2019.
• Effect of heat treatment on the anti-tumor activity of lactoferrin in human colon tumor (HT29) model. Journal of Agricultural and Food Chemistry, 2019.
• Toxicology studies of furosine in vitro/in vivo and exploration of the related mechanism. Toxicology Letters, 2018.
• The toxic effects of aflatoxin B1 and aflatoxin M1 on kidney through regulating L-proline and downstream apoptosis. Biomed Research International, 2018.
• Furosine induced apoptosis by the regulation of STAT1/STAT2 and UBA7/UBE2L6 genes in HepG2 cells. International Journal of Molecular Sciences, 2018.
• Lactoferrin exerts anti-tumor effects by inhibiting angiogenesis in a HT29 human colon tumor model. Journal of Agricultural and Food Chemistry, 2017.