个人简介
Markus Schmid（马科斯 施密德），男，1970年1月生，德国 罗森海姆人，现任瑞典于默奥大学（Umea University）、教授。
施密德 马科斯（Schmid Markus）教授主要从事植物开花调控的研究，围绕Trehalose-6-phosphate signaling、Gibberellic acid signaling、Tissue-specific (epi-) genomics and transcriptomics及miRNA开展了一系列工作，近年又开展了植物响应低温胁迫的基因表达调控机制及基因功能的鉴定。截止2018年5月23日，文章总引用数达10341次。
Email：markus.schmid@umu.se
研究方向
树木生长发育性状形成的分子基础
教育经历
1996年 德国慕尼黑理工大学获得植物学学士学位
1999年 德国慕尼黑理工大学获得植物生物学博士学位
2000-2002年 美国加州the Salk Institute for Biological Studies从事博士后研究
主要学术任职或社会兼职
2002-2015年在德国Max Planck Institute (MPI马普所)任Project Leader, Elected representative of the scientific employees of the MPI for Developmental Biology into the biological-medical section of the Max Planck Society. Served om committees in charge of identifying and evaluating candidate for positions as Max-Planck director.
担任Current Opinion Plant Biology (also section editor); PLoS Genetics (also Associate Guest Editor); Science; Nature; Nature Communications; Nature Plants; Development; PNAS; eLife; Genes & Development; Molecular Plant; Plant Cell; BMC Plant Biology; Journal of Experimental Botany; Molecular Systems Biology; Planta; Plant and Cell Physiology; Plant, Cell and Environment; Plant Physiology; Plant Science; PLoS Biology; Plant Journal; Trends in Plant Science等杂志的section（guest）editor或评审专家。
获奖、荣誉称号、入选重大人才项目情况
Humboldt Foundation, Germany
近5年主要成果
1.Capovilla, G., Delhomme, N., Collani, S., Shutava, I., Bezrukov, I., Symeonidi, E., de Francisco Amorim, M., Laubinger, S.,Schmid, M*.(2018)PORCUPINEregulates development in response to temperature through alternative splicing.Nature Plants(accepted, May 14, 2018).（通讯作者）
2.Shanks, C., Hecker, A., Cheng, C.-Y., Brand, L., Collani, S.,Schmid, M., Schaller, G. E., Wanke, D., Harter, K., Kieber, J. (2018) Role of BASIC PENTACYSTEIENE transcription factors in a sub-set of cytokinin signaling responses.Plant Journal(accepted, Apr. 30, 2018).
3.Prát, T., Hajny,J., Grunewald, W., Vasileva, M., Molnár, G., Tejos, R.,Schmid, M., Sauer, M., Friml, J. (2018) WRKY23 is a Component of the Transcriptional Network Mediating Auxin Feedback on PIN Polarity.PLoS Genetics, 14(1):e1007177. doi: 10.1371/journal.pgen.1007177.
4.Capovilla, G., Symeonidi, E., Wu, R.,Schmid, M*.(2017) Contribution of major FLM isoforms to temperature-dependent flowering inArabidopsis thaliana.Journal Experimental Botany, 68, 5117-5127.（通讯作者）
5.Engelhorn, J., Blanvillain, R., Kroner, C., Parrinello, H., Rohmer, M., Pose, D., Felix Ott, F.,Schmid, M., Carles, C. (2017) Dynamics of H3K4me3 chromatin marks take the lead over H3K27me3 for gene regulation during flower morphogenesis inArabidopsis thaliana.Epigenomes,1,doi:10.3390/epigenomes1020008.
6.You, Y., Sawikowska, A., Neumann, M., Posé, D., Capovilla, G., Langenecker, T., Neher, R.A., Krajewski, P.,Schmid, M*.(2017) Temporal dynamics of gene expression and histone marks at the Arabidopsis shoot meristem during flowering.Nature Communications, 8, 15120, doi: 10.1038/ncomms15120.（通讯作者）
7.Conn, V.M., Hugouvieux, V., Nayak, A., Conos, S.A., Capovilla, G., Cildir, G., Jourdain, A., Tergaonkar, V.,Schmid, M., Zubieta, C., Conn S.J. (2017) A CircRNA from SEPALLATA3 Regulates Splicing of its Cognate mRNA Through R-loop Formation.Nature Plants, 3, doi:10.1038/nplants.2017.53.
8.Pfeiffer, A., Janocha, D., Dong, Y., Medzihradszky, A., Schone, S., Daum, G., Suzaki, T., Forner, J., Langenecker, T., Rempel, E.,Schmid, M., Wirtz, M., Hell, R., Lohmann, J.U. (2016) Integration of light and metabolic signals for stem cell activation at the shoot apical meristem.eLife, 2016;5:e17023.
9.Sayou, C., Nanao, M.H., Jamin, M., Posé, D., Thévenon, E., Grégoire, L., Tichtinsky, G., Denay, G., Ott, F., Peirats Llobet, M.,Schmid, M., Dumas, R., Parcy, F. (2016) A SAM oligomerization domain shapes the genomic binding landscape of the LEAFY transcription factor.Nature Communications, 7, doi:10.1038/ncomms11222.
10.Galvao, V., Collani, S., Horrer, D.,Schmid, M*.(2015) Gibberellic acid signaling is required for ambient temperature-mediated induction of flowering inArabidopsis thaliana.Plant Journal, 84, 949-962.（通讯作者）
11.Lutz, U., Posé, D., Pfeifer, M., Gundlach, H., Hagmann, J., Wang, C., Weigel, D., Mayer, K.F.X.,Schmid, M., Schwechheimer, C. (2015) Modulation of ambient temperature-dependent flowering inArabidopsis thalianaby natural variation ofFLOWERING LOCUS M.PLoS Genetics, 11, e1005588.
12.Slane, D., Kong, J., Kolb, M.,Schmid, M., Jürgens, G., Bayer, M. (2015) Profiling of embryonic nuclear vs. cellular RNA in Arabidopsis thaliana.Genomics Data, 4, 96-98.
13.Valentim, F. L., van Mourik, S., Posé, D., Kim, M. C.,Schmid, M., van Ham, R.C.H.J., Busscher, M., Sanchez-Perez, G.F., Molenaar, J., Angenent, G.C., Immink, R.G.H., van Dijk, A. D. J. (2015) A quantitative and dynamic model of the Arabidopsis flowering time gene regulatory network.PLoS One, DOI: 10.1371/journal.pone.0116973.
14.Slane, D., Kong, J., Kolb, M., Berendzen, K. W., Kilian, J., Henschen, A.,Schmid, M., Harter, K., Mayer, U., de Smet, I., Bayer, M., Jürgens, G. (2014) Cell type-specific transcriptome analysis in the earlyArabidopsis thalianaembryo.Development, 141, 4831-4840.
15.Zhurov, V., Navarro, M., Bruinsma, K. A., Arbona, V., Santamaria, M. E., Cazauxa, M., Wybouw, N., Osborne, E. J., Ens, C., Rioja, C., Vermeirssen, V., Rubio-Somoza, I., Krishna, P., Diaz, I.,Schmid, M., Gómez-Cadenas, A., Van de Peer, Y., Grbic, M., Clark, R. M., Van Leeuwen, T., Grbic, V. (2014) Reciprocal responses in the interaction between Arabidopsis and the cell-content feeding chelicerate herbivore Tetranychus urticae.Plant Physiology, 164, 384-399.
16.Posé, D., Verhage, L., Ott, F., Yant, L., Mathieu, J., Angenent, G. C., Immink, R. G. H.,Schmid, M*. (2013) Temperature-dependent regulation of flowering by antagonistic FLM variants.Nature, 503, 414-417.（通讯作者）
17.Lee, J. H., Ryu, H.-S., Chung, K. S., Posé, D., Kim, S.,Schmid, M., Ahn, J. H. (2013) Regulation of ambient temperature-responsive flowering by MADS-box transcription factor repressor complexes.Science, 342, 628-632.
18.Wahl, V., Ponnu, P., Schlereth, A., Arrivault, S., Langenecker, T., Franke, A., Feil, R., Lunn, J. E., Stitt, M.,Schmid, M*.(2013) Regulation of flowering by trehalose-6-phosphate signaling in Arabidopsis thaliana.Science, 339, 704-707.（通讯作者）
19.Galvao, V., Horrer, D., Küttner, F.,Schmid. M*. (2012) Spatial control of flowering by DELLA proteins in Arabidopsis thaliana.Development, 139, 4072-4082.（通讯作者）
20.Yu, S., Galvao, V., Zhang, Y.-C., Horrer, D., Zhang, T.-Q., Hao, Y.-H., Feng, Y.-Q., Wang, S.,Schmid, M., Wang, J.-W. (2012) Gibberellin controls Arabidopsis floral transition through miR156-targeted SPL transcription factors.Plant Cell, 24, 3320-3332.
21.Brandt, R., Salla-Martret, M., Bou-Torrent, J., Musielak, T., Stahl, M., Lanz, C., Ott, F.,Schmid, M., Greb, T., Schwarz, M., Choi,, S. B., Barton, K. M., Reinhart, B. J., Liu, T., Quint, M., Palauqui, J. C., Martínez-García, J. F., Wenkel, S. (2012) Genome-wide binding-site analysis of REVOLUTA reveals a link between leaf patterning and light-mediated growth responses.Plant Journal, 72, 31-42.
22.Immink, R. G. H., Posé, D., Ferrario, S., Ott, F., Kaufmann, K., Valentim, F. L., de Folter, S., van der Wal, F., van Dijk, A. D. J.,Schmid, M., Angenent G. C. (2012) Characterisation of SOC1's central role in flowering by the identification of its up- and downstream regulators.Plant Physiology, 160, 433-449.
23.Galvao, V., Nordstrom, K., Lanz, C., Sulz, P., Mathieu, J., Posé, D.,Schmid, M., Weigel, D., Schneeberger, K. (2012) Synteny-based mapping-by-sequencing enabled by targeted enrichment.Plant Journal, 71, 517-526.
24.Dinh, T. T., Gierke, T., Liu, X., Yant, L.,Schmid, M., Chen, X. (2012). The floral homeotic protein APETALA2 recognizes and acts through an AT-rich sequence element.Development, 139, 1978-1986.
25.Moyroud, E., Minguet, E. G., Ott, F., Yant, L., Pose, D., Monniaux, M., Blanchet, S., Bastien, O., Thevenon, E., Weigel, D.,Schmid, M., Parcy, F. (2011)Prediction of regulatory interactions from genome sequences using a biophysical model for the Arabidopsis LEAFY transcription factor.Plant Cell, 23, 1293-306.
26.Wahl, V., Brand, L.H., Gou, Y.,Schmid, M*.(2010) The FANTASTIC FOUR proteins influence shoot meristem size in Arabidopsis thaliana.BMC Plant Biology, 10, 285.（通讯作者）
27.Yant, L. J., Mathieu, J., Dinh, T. T., Ott, F., Lanz, C., Wollmann, H., Chen, X.,Schmid, M*. (2010) Orchestration of the floral transition and floral development in Arabidopsis by the bifunctional transcription factor APETALA2.Plant Cell, 22, 2156-2170.（通讯作者）
28.Koo, S. C., Bracko, O., Park, M. S., Schwab, R., Chun, H. J, Park, K. M., Seo, J. S., Grbic, V., Balasubramanian, S.,Schmid, M., Godard, F., Yun, D. J., Lee, S. Y., Cho, M. J., Weigel, D., Kim, M. C. (2010)Control of Lateral Organ Development and Flowering Time by the Arabidopsis thaliana MADS-box Gene AGAMOUS-LIKE6.Plant Journal, 62, 807-816.
29.Schlereth, A., Moller, B., Liu, W., Kientz, M., Flipse, J., Rademacher, E. H.,Schmid, M., Jurgens, G., Weijers, D. (2010).MONOPTEROS controls embryonic root initiation by regulating a mobile transcription factor.Nature, 464, 913-916
30.Mathieu, J., Yant, L. J., Mürdter, F., Küttner, F.Schmid, M*. (2009) Repression of flowering by the miR172 target SMZ.PLoS Biology, 7, e1000148.（通讯作者）
31.Helm, M.,Schmid, M., Hierl, G., Terneus, K., Tan, L., Lottspeich, F., Kieliszewski, M.J., Gietl, C. (2008) KDEL-tailed cysteine endopeptidases involved in programmed cell death, intercalation of new cells, and dismanteling of extensin scaffolds.American Journal of Botany, 95, 1049-1062.
32.Dohmann, E.M.N., Levesque, M.P., Isono. E.,Schmid, M., Schwechheimer, C. (2008) Auxin responses in mutants of the Arabidopsis CPO9 signalosome.Plant Physiology, 147, 1369-1379.
33.Dohmann, E.M.N., Levesque, M.P., De Veylder, L., Reichardt, I., Juergens, G.,Schmid, M., Schwechheimer, C. (2008) The Arabidopsis COP9 signalosome is essential for G2 phase progression and genomic stability.Development, 135, 2013-2022.
34.Mathieu, J., Warthmann, N., Küttner, F.,Schmid, M*. (2007) Export of FT protein from phloem companion cells is sufficient for floral induction in Arabidopsis.Currents,17, 1055-1060.（通讯作者）
35.Henz, S.R., Cumbie, J.S., Kasschau, K.D., Lohmann, J.U., Carrington, J.C., Weigel, D.,Schmid, M*. (2007) Distinct expression patterns of natural antisense transcripts in Arabidopsis.Plant Physiology, 144, 1247-1255.（通讯作者）
36.Wigge, P. A., Kim, M. C., Jaeger, K. E., Busch, W.,Schmid, M., Lohmann, J. U., Weigel, D. (2005) Integration of spatial and temporal information during floral induction in Arabidopsis.Science, 309, 1056-1059.
37.Schmid, M., Davison, T. S., Henz, S. R., Pape, U. J., Demar, M., Vingron, M., Scholkopf, B., Weigel, D., Lohmann, J. U. (2005) A gene expression map of Arabidopsis thaliana development.Nature Genetics, 37, 501-507. （第一作者）
38.Schwab, R., Palatnik, J. F., Riester, M., Schommer, C.,Schmid, M., Weigel, D. (2005) Specific Effects of MicroRNAs on the Plant Transcriptome.Developmental Cell, 8(4), 517-527.
39.Lempe, J., Balasubramanian, S., Sureshkumar, S., Singh, A.,Schmid, M., Weigel, D. (2005) Diversity of flowering responses in wild Arabidopsis thaliana strains.,PLoS Genetics, 1(1), e6.
40.Schmid, M., Uhlenhaut, N. H., Godard, F., Demar, M., Bressan, R., Weigel, D., Lohmann, J. U. (2003) Dissection of floral induction pathways using global expression analysis.Development, 130, 6001-6012. （第一作者）
41.Schumann, U., Wanner, G., Veenhuis, M.,Schmid, M., Gietl, C. (2003) AthPEX10, a nuclear gene essential for peroxisome and storage organelle formation during Arabidopsis embryogenesis.Proceedings National Academy Science USA, 100, 9626-9631.
42.Alonso, J. M., Stepanova, A. N., Leisse, T. J., Kim, C. J., Chen, H., Shinn, P., Stevenson, D. K., Zimmerman, J., Barajas, P., Cheuk, R., Gadrinab, C., Heller, C., Jeske, A., Koesema, E., Meyers, C. C., Parker, H., Prednis, L., Ansari, Y., Choy, N., Deen, H., Geralt, M., Hazari, N., Hom, E., Karnes, M., Mulholland, C., Ndubaku, R., Schmidt, I., Guzman, P., Aguilar-Henonin, L.,Schmid, M., Weigel, D., Carter, D. E., Marchand, T., Risseeuw, E., Brogden, D., Zeko, A., Crosby, W. L., Berry, C. C., Ecker, J. R. (2003) Genome-Wide Insertional Mutagenesis of Arabidopsis thaliana.Science, 301, 653-657.
43.Schmid, M., Simpson, D., Sarioglu, H., Lottspeich, F., Gietl, C. (2001) The ricinosomes of senescing plant tissue bud from the endoplasmic reticulum.Proceedings National Academy Science USA, 98, 5353-5358. （第一作者）
44.Schmid, M., Simpson, D., Gietl, C. (1999) Programmed cell death in castor bean endosperm is associated with the accumulation and release of a cysteine endopeptidase from ricinosomes.Proceedings National Academy Science USA, 96, 14159-14164. （第一作者）
45.Wimmer, C.,Schmid, M., Veenhuis, M., Gietl, C. (1998) The plant peroxisomal targeting signal 1-receptor: similarities and differences to its human and yeast counterparts.Plant Journal, 16, 453-464.
46.Schmid, M., Simpson, D., Kalousek, F., Gietl, C. (1998) A cysteine endopeptidase with a C-terminal KDEL motif isolated from castor bean endosperm is a marker enzyme for the ricinosome, a putative lytic compartment.Planta, 206, 466-475. （第一作者）
47.Capovilla, G., Pajoro, A., Immink, R. G. H.,Schmid, M*. (2015) Role of alternative pre-mRNA splicing in temperature signaling.Current Opinion Plant Biology, 27, 97-103.（通讯作者）
48.Capovilla, G.,Schmid, M., Posé, D. (2015) Control of flowering by ambient temperature.Journal Experimental Botany, 66, 59-69.
49.Galvao, V.,Schmid, M*. (2014) Regulation of flowering by endogenous signals.Advances Botanical Research, 72, 63-102.（通讯作者）
50.Pose, D., Yant, L.,Schmid, M*. (2012) The end of innocence: flowering networks explode in complexity.Current Opinion Plant Biology, 15, 45-50.（通讯作者）
51.Ponnu, J., Wahl, V.,Schmid, M*. (2011) Trehalose-6-Phosphate signaling: insights into plant development.Frontiers Plant Physiology, 2:70. doi: 10.3389/fpls.2011.00070.（通讯作者）
52.Huijser, P.,Schmid, M*. (2011) The control of developmental phase transitions in plants.Development, 138, 4117-4129.（通讯作者）
53.Srikanth, A.,Schmid, M*. (2011) Regulation of flowering time: all roads lead to Rome.Cellular & Molecular Life Sciences, 68, 2013-2037.（通讯作者）
54.Yant, L. J., Mathieu, J.,Schmid, M*. (2009) Just say no: floral repressors help Arabidopsis bide the time.Current Opinion Plant Biology, 12, 580-586.（通讯作者）
55.Gietl, C.,Schmid, M*. (2001) Ricinosomes: an organelle for developmentally regulated programmed cell death in senescing plant tissues.Naturwissenschaften, 88, 49-59.（通讯作者）
56.Gietl, C., Schmid, M., Simpson, D. (2000) Ricinosomes and aleurain-containing vacuoles (AVCs): protease-storing organelles. In “Vacuolar Compartments” edited by Robinson, D. G. and Rogers, J. C., Sheffield Academic Press.
Submitted manuscripts：
1. Speth, C. Szabo, E. X., Martinho, C., Collani, S., zur Oven-Krockhaus, S., Richter, S., Droste-Borel, I., Macek, B., Stierhof, Y-D.,Schmid, M., Liu, C., Laubinger, S. (2018) Arabidopsis RNA processing factor SERRATE regulates the transcription of intronless genes.eLife(submitted, Apr. 16, 2018).
2. You, Y., Sawikowska, A., Lee, J. E., Benstein, R., Neumann, M., Krajewski, P.,Schmid, M.(2018) Phloem companion cell-specific transcriptomic and epigenomic analyses identify MRF1, a novel regulator of flowering.Plant Cell(under revision).
3 Collani, S., Neumann, M., Yant, L.,Schmid, M.(2018) Effects of FLOWERING LOCUS T on FD during the transition to flowering at the shoot apical meristem ofArabidopsis thaliana.Plant Cell(under revision).
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